![]() Fomepizole (4-methylpyrazole), a clinically approved antidote against methanol and ethylene glycol poisoning, recently emerged as a promising candidate. Thus, additional antidotes with an extended therapeutic window may be needed for these patients. However, for late-presenting patients or after ingestion of very large overdoses, the efficacy of NAC is diminished. The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure.
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